You know I love that organic cooking…

userpic=caduceusLet’s continue the trend of using lyrics in titles, although many of us will start singing just from the title line alone. Let’s see if this helps:

You know I love that organic cooking
I always ask for more
And they call me Mr Natural
On down to the health food store
I only eat good sea salt
White sugar don’t touch my lips
And my friends is always begging me
To take them on macrobiotic trips
Yes, they are

Tonight’s collection of news chum has to do with the intertwined topics of food and medicine, including some studies that indicate that some of what we thought might be completely wrong:

  • Oil Me Up. Oil Me Down. For years, what has been the mantra: Vegetable oil good. Butter bad. Grapeseed oil good for high heat. Olive oil best raw. Oh, and never never never go for that palm or coconut oil. Turns out, what we know about cooking with oils may be completely wrong. Based on some recent studies, scientists are now warning against the dangers of frying food in sunflower oil and corn oil over claims they release toxic chemicals linked to cancer. These leading scientists are now recommending food be fried in olive oil, coconut oil, butter or even lard.  Scientists found that heating up vegetable oils led to the release of high concentrations of chemicals called aldehydes, which have been linked to illnesses including cancer, heart disease and dementia. This goes along with some other research that is showing that whole milk may be much better for you than low-fat or skim.
  • GMO Salmon Safe. This week, the FDA approved consumption of genetically modified salmon. Now, I love salmon as much as the next guy, but even this gave me pause. Do I want to eat it? Turns out, genetically modified salmon appears actually to be safe to eat. The article goes through a number of the fears, including the complaint that it endangers consumers’ “personal health,” that it “could cause human allergies,” and that it’s been approved based on “insufficient safety testing.” In the case of GE plants, these scary what-if arguments are unfalsifiable, based on speculation about chemical properties and ever-expanding demands for longer study periods and bigger samples. The GE salmon was initially submitted for FDA approval 20 years ago. The agency declared it safe in 2010 and then spent another five years reviewing objections. Thursday’s statement says the FDA has concluded that the salmon is “safe to eat” and is “as nutritious as food from other non-GE Atlantic salmon.” It also says the genetic change is “safe for the fish itself.” There are loads of links in the Slate article, so decide for yourself.
  • Overweight Bad? Here’s another study of interest that shows that being moderately overweight may not be as bad for your health as once thought. I’ll emphasize moderately. Being overweight is now believed to help protect patients with an increasingly long list of medical problems, including pneumonia, burns, stroke, cancer, hypertension, and heart disease. Researchers who have tried to show that the paradox is based on faulty data or reasoning have largely come up short. And while scientists do not yet agree on what the paradox means for health, most accept the evidence behind it. “It’s been shown consistently enough in different disease states,” says Gregg Fonarow, a cardiology researcher at the University of California, Los Angeles. They aren’t sure why.  My thoughts: it isn’t being overweight — it is really that we’re miscalculating what a healthy weight is. In fact, it could very well be that, just as in the next item, what is a healthy over- or under-weight value may vary by the individual.
  • Diets are Individualistic.  It turns out that what may be the best diet for one may not be the best diet for another. Researchers Eran Elinav and Eran Segal of the Weizmann Institute of Science have just published the results of a large, comprehensive study in the journal Cell that found people can metabolize the exact same foods in very different ways. What this means is that a healthy diet for one person may not be healthy for another person. Rather than recommend a cookie-cutter solution to weight problems, the researchers say, doctors could be more effective by recommending a personalized nutrition plan to a patient, based on the way that patient metabolizes certain foods.  Again, this doesn’t surprise me: obesity and health is increasingly being shown to be dependent on  our individual gut biome, which we’ve been systematically destroying.
  • Bed May Be Bad. We start to move away from the food a bit now. Here’s an article on a study that sleeping in (as you do on the weekends) may be bad for you. Disruptions to routine sleeping patterns can increase the danger for developing metabolic diseases for example diabetes and heart disease, according to a brand new study. New research conducted at the University of Pittsburgh demonstrates that societal jetlag as basic as getting up late may also be bad for health. Social jetlag refers to a mismatch between an individual ‘s socially-imposed sleep program and their natural circadian rhythm. Researchers said societal jetlag is understood to relate to obesity and other cardiovascular conditions, yet the connection to healthy individuals is fresh. Doesn’t surprise me at all: I tend to get less migraines if I keep my sleep cycle regular.
  • Potential New Migraine Preventative. Scientists may have finally come up with an effective migraine preventative. This is wonderful news. We’ve started to have drugs that can stop an attack in progress. Prevention? We’ve adapted blood pressure drugs (which I use), depression medications, epilepsy meds, and even Botox to try to prevent them. It doesn’t always work (I know I go through periods where I’ve got light migraines almost every other day). However, neurologists believe they have identified a hypersensitive nerve system that triggers the pain and are in the final stages of testing medicines that soothe its overly active cells. These are the first ever drugs specifically designed to prevent the crippling headaches before they start, and they could be approved by the U.S. Food and Drug Administration next year. If they deliver on the promise they have shown in studies conducted so far, which have involved around 1,300 patients, millions of headaches may never happen. The work focuses on the trigeminal nerve system, long known to be the brain’s primary pain pathway. Studies in animals indicated that in branches of the nerve that exit from the back of the brain and wrap around various parts of the face and head, overactive cells would respond to typically benign lights, sounds and smells by releasing chemicals that transmit pain signals and cause migraine. The heightened sensitivity of these cells may be inherited; 80 percent of migraine sufferers have a family history of the disorder. This makes sense to me: when my migraines started, I could touch near my nose and feel it around to the back of my neck — in other words, the trigeminal nerve was over-sensitive.
  • Addressing Blood Pressure. Another concern of mine is blood pressure. I’m on a combination of meds to get it down, but I’m still routinely in the 140-130/90-80 range, and they now want a target of under 120/80. Here’s a great article I ran across on other things to do to lower blood pressure. I’m trying to lose weight and exercise, but it is hard when you’re getting home at 5:30p and want to have dinner by 8pm.
  • The Brain GPS. I’ve always said that everyone is experts in remembering something, and my particular expertise is spatial and temporal. I can remember the layout of rooms I haven’t been in for 20 years. I have maps in my head and innately know where I am (except in the twisty maze of roads near John Wayne Airport). I invariably come back in the kitchen when there is just 10 seconds on the timer. Turns out: there is a brain GPS, and it helps with our memories. A recent animal study found that special brain cells that track an animal’s location also can track time and distance. This could explain how rat and human brains are able to organize memories according to where and when an event occurred. The cells, called grid cells, appear to be “laying down the sequence of space and time that provide a framework for events that are unfolding,” says Howard Eichenbaum, an author of the study and director of the Center for Memory and Brain at Boston University.

Going back to the song, have you figured it out yet. Perhaps some more will help:

Oh, but at night I stake out my strong box
That I keep under lock and key
And I take it off to my closet
Where nobody else can see
I open that door so slowly
Take a peek up north and south
Then I pull out a Hostess Twinkie
And I pop it in my mouth
Yeah, in the daytime I’m Mr Natural
Just as healthy as I can be
But at night I’m a junk food junkie
Good lord have pity on me

Speaking of Junk Food, how about a run for the border. In this case, I’m talking a specific Taco Bell, “Numero Uno”, which was saved from demolition and moved last night from Downey to Irvine. That is south of the border. Well, at least south of the Orange Curtain.

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Science and Health News Chum: Detecting Gluten, Medicine Notes, Sex, Plastic, and Love

userpic=mad-scientistAs I noted in my highway headline post, it’s been very busy around here. Still, I’ve collected a few articles of interest. This collection is all connected by being related to recent science and health discoveries:

  • Detecting Gluten. One article I read recently led me to discover a handheld sensor about to hit the market: the Nima sensor. Nima, is a portable, handheld gluten detector. Users load a half-teaspoon sample of food into a test tube and pop that into a triangle-shaped sensor. (They’ll need to use a new disposable capsule for each test to avoid cross-contamination.) The sensor assesses the contents of the capsule—detecting trace elements of gluten down to 20 parts per million—and then spits out a “yes” or “no” within two minutes. “No” signals that the food is safe to eat; a “yes” indicates that gluten is present. We’ve added ourselves to the mailing list for more info.
  • Generic Medicines. Recently, I was prescribed a blood pressure medicine that was almost $100 after insurance (I’ve since switched to a generic that is much cheaper). With that experience, the problem with the pricing of generics was on my mind — and so this article on the pricing of generic medicines caught my eye. Part of the problem is bioequivalence studies. Generic drugs don’t need the excruciatingly drawn-out safety and efficacy studies required of new brand-name medications, but they do need to pass a bioequivalency study proving that their drug is absorbed the same way as the original. According to Wikipedia, the most common type of bioequivalence study is to “measure the time it takes the generic drug to reach the bloodstream in 24 to 36 healthy volunteers; this gives them the rate of absorption, or bioavailability, of the generic drug, which they can then compare to that of the innovator drug”. Making the chemical is cheap. If you also want FDA approval, it costs $2 million and takes two years. There’s also the problem of how pharmacies and insurance companies price things. It’s an interesting read.
  • Timing of Medicines. I mentioned blood pressure meds above. Here’s an interesting note related to that: taking your blood pressure meds before bed instead of in the morning lowers your diabetes risk. In one study, when adjusted for age, waist circumference, glucose, chronic kidney disease, and hypertension treatment the researchers found sleeping blood pressure was the most significant predictor of diabetes risk, while waking blood pressure was found to have no predictive value. A second study found, when accounting for age, waist circumference, glucose, chronic kidney disease and specific treatment, that taking the blood pressure medications at night resulted in a 57 percent decrease in the risk of developing diabetes.
  • Male Birth Controls. A new approach has been found towards a possible male birth control pill. This approach doesn’t focus on hormones, but proteins. A study in mice focused on a protein called calcineurin, which is found in the sperm-producing cells of the testes as well as other cells in the body. The researchers genetically engineered mice so that they lacked a gene that makes part of the calcineurin protein but is activated only in sperm-producing cells. When these mice had sex, they were infertile, the researchers said. When the researchers tried to figure out why their genetically engineered mice were infertile, they found that the mice’s sperm cells did not swim well and were not able to fertilize eggs. Further experiments found that the midpieces of these sperm didn’t bend normally, which prevented the sperm from penetrating the membrane of an egg. Now to see if this works with humans.
  • Ringing in the Ears. One side effect of my migraines is tinitus — what some call “ringing” in the ears, but which (for me) is a high-pitched squeal. For the longest time, we didn’t know what caused it…. but now we do. It turns out it shares a common source with chronic pain. Doctors compared tinnitus patients with those who did not have tinnitus and found volume loss in the medial prefrontal cortex, an area that plays a role in the limbic system and functions as a “gate” or control area for noise and pain signals that is also associated with depression. This is an area that also lights up when you play unpleasant noises, so it has to do with unpleasant sensations. They found the ventromedial prefrontal cortex and the nucleus accumbens are part of a “gatekeeping” system that determines which sounds or other stimuli to admit. When the system is defective, affected patients can be subjected to constant stimuli and long-lasting disturbances. The area is also associated with depression and anxiety, conditions often arise “in lockstep” with chronic pain. Because of this, the researchers are now looking to drugs that regulate that system, like dopamine and serotonin, to restore the gatekeeping role and eliminate the chronic pain, but more research is needed.
  • Eliminating Plastics. One of the scourges of the model world is plastic. Very useful, it is also not biodegradable and becomes the waste that will list forever. But then again… it turns out the mealworms and mealmoth larvae eat plastic and generate biodegradable poop from it. This explains how they get into food wrapped in plastic.  Being serious: Larvae of the darkling beetle will not only feed on expanded polystyrene, but microorganisms in their guts biodegrade it internally. And then, they poop out a seemingly safe product that may be suitable as soil for crops. Another surprise is that the PS doesn’t seem to be toxic to the insects. This work is building on research initiated at the Beihang University in China, where researchers observed waxworms, the larvae of Indian mealmoths, break down polyethylene in the form of plastic bags thanks to microorganisms in their guts. So far, the excreted waste appears safe to use as soil.
  • Picking a Boy/Girlfriend. Ever wonder why you don’t think your best friend’s partner is cute? Ever wonder why you think your love is beautiful, but no one else does? Science has figured out why.  According to a new study, it’s our life experiences—not a perfectly chiseled jaw or sultry bedroom eyes—that make a person’s face appealing to us. Sure, symmetrical features are generally more attractive than non-symmetrical ones, but an even face only partially accounts for someone’s overall “attractiveness,” researchers find. Physical attraction is highly personal—even among relations who’ve had similar upbringings. Researchers chalked up the differences to our own distinct life experiences, which can vary widely thanks to co-workers, peers, past relationships, and media exposure. Essentially, if you’ve had good experiences with people who have certain facial characteristics, you’ll most likely find them attractive. As time passes, others who look like them will seem good-looking to you as well.

 

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Swabbing the Rest of the Deck

userpic=pirateNow, mates, time to swab the rest of the deck. The cookee said that he couldn’t use these tasty chunks in the stew — they just didn’t blend right. He says we should throw them overboard:

Music: Ghost Brothers Of Darkland County (2010 Studio Cast):Brotherly Love” (Ryan Bingham and Will Dailey)

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Mothers Day News Chum Stew

Observation StewYou know you want to take your mother to dinner. But what will you talk about? Here’s a bunch of news chum stew items, accumulated over the last two weeks (I’ve been busy, what can I say) that might just do:

  • Size Matters. Here’s a great discussion topic for your mom… or for “Wait Wait, Don’t Tell Me”. A recent study has shown that, the larger your penis, the greater the likelihood that your wife will cheat on you. In particular, according to this study, every one inch longer penis increased the likelihood of women being involved in extra-marital partnership by almost one-and-half times. I think I’ll leave the subject at that and go on to the next subject…
  • Got Gas? Here’s some more useful information. Remember “Beans Beans They’re Good for the Heart”. Well, it turns out that lots of gas is a sign of a healthy biome in your gut. This reminds me of a joke from Jason Alexander. It seems there was this long married couple whose sex life was in the dumps (see item #1). The wife went to a sex counselor, who suggested they try 69. She came home and explained it to her husband. They got in bed and in the position…. and she ripped a good one. After the air had cleared, they tried it again… and she ripped another one. They were about to try it again when the husband said, “you think I’m going to do this 67 more times, you’re crazy”.
  • It’s the Place To Be. Yup, that Farm Living is the life for me. If this makes you think of Green Acres, you’re not along. There are plans for a Broadway stage play adaptation of the hicksville TV show originally starring Eddie Albert and Eva GaborThe rights to the property were acquired by director Richard L. Bare, who was one of the most prolific helmers on the original series, and by producer Phillip Goldfine through his production company Hollywood Media Bridge.
  • Cramming It In. Sony is working on new technology that will cram 3,700 blue-rays into a single cassette tape. Actually, that’s a little misleading — we’re not talking here about a C-60 or a C-90, but a specially designed cartridge. Still, the technology is intriguing: a whopping 148 GB per square inch, meaning a cassette could hold 185 TB of data. Sony uses a vacuum-forming technique called sputter deposition to create a layer of magnetic crystals by shooting argon ions at a polymer film substrate. The crystals, measuring just 7.7 nanometers on average, pack together more densely than any other previous method. The result is that three Blu-Rays’ worth of data can fit on one square inch of Sony’s new wonder-tape.
  • A Touching Story. Here’s a very touching story about a late night encounter in a supermarket, told by Mark Evanier.
  • Anything But Starbucks. A touching obituary for Herman Hyman, founder of the Coffee Bean and Tea Leaf chain. This chain, which roasts its beans in Ventura County, started in a small store on San Vicente Blvd in Brentwood in the 1970s. I think, in fact, that it started not far from my first condo.
  • Buildings Up, Buildings Down. Two interesting buildings in the news. First, the plans have been announced for the former furniture store space across from the Pasadena Playhouse. Should be an interesting project; it will be interesting to see how it changes the character of that area. In Las Vegas news, approval has been given to finally take down the Harmon. If you aren’t familiar with the Harmon, it is the oval blue-glass coated skyscraper next to the Aria and Vdara, across from Planet Hollywood and the Cosmopolitan. It was built wrong and is unstable, but they can’t implode it because it is too close to other stuff. They have to take it down piece by piece. Now if only they could do something with the Fountainbleau, which is an even bigger eyesore on the N end of the strip (where the Thunderbird once was).

 

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Saturday Stew: Clearing out the Groupatwos before Pesach

Observation StewIn the Talmud, there is a learned Rabbi who opines that groupatwos are to be considered Chametz during Passover. Luckily, this week was so busy I accumulated a bunch of groupatwos. So let’s get that feather and that candle and get them out of the links list before Passover starts Monday night:

 

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It’s the Littlest Things…

userpic=observationsToday’s collection of lunchtime news chum stories all have to do with the littlest things having big effects:

  • High-O Silver! Recently, my wife picked up a new antibiotic gel at the pharmacy — an over-the-counter colloidal silver creme. I thought nothing of it (other than to try it and see it worked well) — after all, there are people who use colloidal silver to fight infections, although it has the side effect of turning your skin blue. Additionally, according to numerous studies, consumers may benefit from the silver specks’ ability to inhibit the growth of bacteria, fungus and other microorganisms, including disease-causing Escherichia coli and Staphylococcus aureus. So, I was intrigued by this Discover article about the new silver antibiotic gel — it seems that it contains silver nanoparticals that may harm humans and wildlife. The problem is that silver nanoparticles’ tiny size allows them to enter parts of living things bodies that other molecules can’t reach. This can damage the inner workings of cells and inhibit protein production.  And of course, being stupid humans, we’re just tossing this stuff into the environment, along with plastic nanoparticles, gold nanoparticles, and copper nanoparticles.
  • Battling the Bulge. Everyone has heard, by now, of the various bariatric surgical approaches for weight loss. Two of the best approaches are the Roux-en-Y gastric bypass operation and the vertical sleeve gastrectomy. One might think that these approaches work by reducing the size of the stomach, and thus reducing the amount of food one can eat and/or absorb. But if you think that, you would be wrong. There’s some new research on how obesity surgery really works, and it is astounding. It appears that these surgeries actually work by setting in motion a cascade of signaling changes in the gut and elsewhere. Those changes, in turn, reshape the mix of gut bacteria in ways that appear to turn up metabolic function, lipid metabolism and signals that tell the brain it’s time to stop eating. Researchers have already observed that certain bile acids circulate more copiously in the guts and blood of patients in the wake of bariatric surgery, but could only guess at why. They also have observed that the community of bacteria colonizing the guts of obese patients changes in the wake of bariatric surgery. Researchers just found that that one link between these two changes is a genetic “switch,” or transcription factor, called FXR. Increased bile acid unlocks FXR, which improves metabolic function directly. But improved FXR signaling also promotes the growth of gut bacteria that help regulate fat metabolism, and suppresses gut bacteria that is linked to weight gain and metabolic disturbance. The next step is to figure out how to create the FXR signalling through medicine, not surgery.
  • Concrete Isn’t Forever. Most of us see something made of concrete, and we think “permanence” (well, I also wonder about the water trapped in the structure). But all of our concrete isn’t permanent, and that’s creating a problem. Here’s the scary headline related to this that caught my eye: Concrete-Dissolving Bacteria Are Destroying Our Sewers. The problem is that, within the sewer system, one set of microbes emits hydrogen sulfide, the gas that is also responsible for raw sewage’s unpleasant smell. This gas fills the empty space between the top of the pipe and the water flow. Another set of microbes living in this headspace turns hydrogen sulfide to sulfuric acid, which eats away at concrete, leaving behind gypsum, the powdery stuff you find in drywall. This turns the sewer pipes into wet drywall. Yuk. That’s worse than Orangeberg piping. The current solution is to put plastic liners into the concrete pipes, a process that is almost as expensive as digging them up entirely. A better approach might be to embed anti-bacteria in the concrete (but that can build resistance). Microbiologists are instead thinking about how to tinker with the water systems and DNA sequencing to create probacteria — bacteria in the water pipes that are harmless to humans (so they say) but can manage the sewer bacteria.
  • [ETA] Bugs from Birth. Here’s a P.S. item from Andrew Ducker on how the birth process was designed to colonize us with beneficial microbes that help keep the bad ones out. The implication of this is that, as more and more women opt go to the Caesarian route for convenience, we are entering life less prepared with the good stuff we need to get us started. As the article notes, “the founding populations of microbes found on C-section infants are not those selected by hundreds of thousands of years of human evolution or even longer.” In other words — we are too safe for our own good.

Scientists like to say that this is a bacteria’s world, and we just live with it. After all, humans carry more bacteria cells than human ones, and without bacteria, we couldn’t live in the world. In fact, small microbes now are believed to be responsible for one of the greatest mass extinctions on earth! We need to think more about our indiscriminate use of antibiotics,  and the impacts of our growing use of nanotechnology that we don’t fully understand.

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Thanksgiving Left-Over News Chum Stew

Observation StewAh, the weekend after Thanksgiving. Time to sit down to a hearty bowl of Turkey Stew, with nice chucks of news:

  • Smelling The Subway. This is a real interesting article (and quite likely of interest to Andrew Ducker and those in the UK). A fellow who has synaesthesia, a neurological condition which prompts an involuntary reaction to sensory experiences, tastes things that he hears. In particular, place names provoke real tastes and intense cravings for particular foods. Using this knowledge, he has made a “taste map” of the London Underground. For example, to this fellow, Tottenham Court Road provokes a particularly strong taste of a sausage and egg breakfast, whilst nearby Bond Street prompts the less appealing tang of hairspray. Among the flavors that appear on the map are apple pie, bubble and squeak, HP sauce, purple grapes, chicken soup and soft boiled egg. Others include sweets such as love hearts, poppets, soft wine gums and jelly tots. Obscure flavors include coal dust, putrid meat, burnt rubber, wet wool, pencil eraser, fuzzy felt and dried blood.
  • Shel Silverstein. One of my favorite warped authors is Shel Silverstein. His kids stuff is great; his adult stuff is even better. He was also an accomplished songwriter, penning many folk and comedy songs. Here’s an interesting article on the unlikely way he rose to fame. Here’s a hint: Whenever you read his children’s stuff, look for the hidden subversive adult message.
  • I’m Bored. Many of us, I’m sure, get bored. But most of us don’t make it their job to boredom. Luckily, there are researchers that do. Did you know, for example, that there are five types of boredom … one more than researchers expected? (Well, you did if you were bored enough to listen to Wait Wait).  The types of boredom that they expected were: (1) Indifferent boredom, a relaxing and slightly positive type of boredom that “reflected a general indifference to, and withdrawal from, the external world”; (2)Calibrating boredom, the slightly unpleasant state of having wandering thoughts and “a general openness to behaviors aimed at changing the situation”; (3) Searching boredom, the kind that makes you feel restless and leaves you “actively seeking out specific ways of minimizing feelings of boredom”; and (4) Reactant boredom, which is so bad that it prompts sufferers “to leave the boredom-inducing situation and avoid those responsible for this situation (e.g., teachers).” What they discovered was a fifth type of boredom: Apathetic boredom. I’d go on, but I’m sure you’re bored by now.
  • Next on Wait Wait. Do you ever see scientific studies, and go “That’ll be on Wait Wait”. Here’s one for Wait Wait: Sexual frustration decreases lifespan — at least in flies. Specifically, the chemical attractant wafting from a female fruit fly shortened the lifespan of male flies when the femme fatale didn’t deliver on the signal’s promise, according to a new study.
  • Oh, How I Hate To Get Up In The Morning. I’m a morning person. In fact, I often get up just shortly before my alarm goes off. Turns out, there’s a reason why. It’s due to having a very accurate body clock. The body happens to love predictability. Your body is most efficient when there’s a routine to follow. So if you hit the hay the same time each night and awake the same time each morning, your body locks that behavior in.  The implication of this, of course, is that having constantly changing bedtimes and waking times puts stress on your body. That’s one of the reasons that, for me, sleeping me means sleeping until 530am.
  • Good News for Steve Stepanek. Dr. Steve Stepanek is one of the folks I work with regularly at CSUN, as he is head of the Computer Science Liaison Council. The Daily Sundial is reporting that Steve just got elected to the CSU Board of Trustees. That’s great news — they’ve got a great educator, an engineer, and a computer scientist (as well as a train aficionado) as a member.
  • Eating the Brain. One last science related item: Scientists have discovered an overlooked type of brain cell that may be responsible for learning. What it does is prune connections (essentially, eating them) in the brain, permitting new connections (and thus new learning) to be recorded. This could carry important implications for the battle against neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, for psychiatric disorders, and for the nagging loss of memory that comes with aging.

 

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Heading It Off

userpic=headacheI’ve written before, numerous times, about how I’m a migraine sufferer. I’m lucky that my migraines are not severe; they are just dull and annoying. I rarely get any aura; my tell is my eye watering and a single-sided headache. Thankfully, I don’t usually need to hide in a dark room, away from stimuli, curled in a ball as many sufferers do. I can usually continue to work, perhaps at a degraded level, through them. They are, however, frequent and annoying.

My current regime uses a beta blocker (propranolol) and a muscle relaxant (tizanidine) as preventatives, and rizatriptan as my abortive. When I saw my neurologist a few weeks ago, she suggested adding another abortive to the mix: an old-line tricyclic antidepressant. They evidently have an off-label use to help block pain receptors. She recommended either nortriptyline or amitriptyline. I indicated I would research them, because I always have a concern of the effect of any medication on my ability to drive the vanpool, and on my mental acuity (which I need for my job). That’s a primary reason why I’ve never considered either topiramate (Topamax) or divalproex sodium (Depakote) as preventatives — both have significant impacts on mental alertness. Propranolol does just fine, and has the additional side effect of helping keep my blood pressure lower.

This week, I’m in a headache cycle (nearly daily, vs. weekly), and so this morning I reviewed the side effects of both nortriptyline and amitriptyline. Both can make one drowsy, and each has potential side effects that aren’t appealing. I’ve also looked at the reviews for each as a migraine preventative (N, A). Both have a lot of positive reviews. Still, I’m hesitant about anything that monkeys with brain chemistry. So, on the off chance anyone reading this has used them, I’d like to know your experiences. This will serve as input to deciding whether to just keep with what I’m doing, or to add one of these.

 

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